Unveiling the role of transgelin as a prognostic and therapeutic target in kidney fibrosis via a proteomic approach.

ABSTRACT: Chronic kidney disease (CKD) progression involves tubulointerstitial fibrosis, a process characterized by excessive extracellular matrix accumulation. To identify potential biomarkers for kidney fibrosis, we performed mass spectrometry-based proteomic profiling of human kidney tubular epithelial cells and kidney tissue from a 5/6 nephrectomy rat model. Multidisciplinary analysis across kidney fibrosis models revealed 351 differentially expressed proteins associated with kidney fibrosis, and they were enriched in processes related to the extracellular matrix, kidney aging, and mitochondrial functions. Network analysis of the selected proteins revealed five crucial proteins, of which transgelin emerged as a candidate protein that interacts with known fibrosis-related proteins. Concordantly,

SUBMITTER: Kwon S 

PROVIDER: S-EPMC11542076 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature