Phenotypic and genetic characteristics of retinal vascular parameters and their association with diseases.

ABSTRACT: Fundus images allow for non-invasive assessment of the retinal vasculature whose features provide important information on health. Using a fully automated image processing pipeline, we extract 17 different morphological vascular phenotypes, including median vessels diameter, diameter variability, main temporal angles, vascular density, central retinal equivalents, the number of bifurcations, and tortuosity, from over 130,000 fundus images of close to 72,000 UK Biobank subjects. We perform genome-wide association studies of these phenotypes. From this, we estimate their heritabilities, ranging between 5 and 25%, and genetic cross-phenotype correlations, which mostly mirror the corresponding phenotypic correlations, but tend to be slightly larger. Projecting our genetic association signals o

SUBMITTER: Ortin Vela S 

PROVIDER: S-EPMC11542103 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature