Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy.

ABSTRACT: Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations to white matter microstructure. We assessed PSMD over the clinical continuum in Dutch-type hereditary CAA (D-CAA) and its association with other CAA-related MRI-markers and cognitive symptoms. We included (pre)symptomatic D-CAA mutation-carriers and calculated PSMD from diffusion-MRI data. Associations between PSMD-levels, cognitive performance and CAA-related MRI-markers were assessed with linear regression models. We included 59 participants (25/34 presymptomatic/symptomatic; mean age 39/58 y). PSMD-levels increased with disease severity and were higher in symptomatic D-CAA mutation-carriers (median [range] 4.90 [2.77-9.50]mm²/s × 10^-4) comp

SUBMITTER: Rasing I 

PROVIDER: S-EPMC11542140 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature