Kinetic modeling of the monoamine oxidase-B radioligand [¹⁸F]SMBT-1 in human brain with positron emission tomography.

ABSTRACT: This paper describes pharmacokinetic analyses of the monoamine-oxidase-B (MAO-B) radiotracer [¹⁸F](S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2-hydroxy)propoxy]quinoline ([¹⁸F]SMBT-1) for positron emission tomography (PET) brain imaging. Brain MAO-B expression is widespread, predominantly within astrocytes. Reactive astrogliosis in response to neurodegenerative disease pathology is associated with MAO-B overexpression. Fourteen elderly subjects (8 control, 5 mild cognitive impairment, 1 Alzheimer's disease) with amyloid ([¹¹C]PiB) and tau ([¹⁸F]flortaucipir) imaging assessments underwent dynamic [¹⁸F]SMBT-1 PET imaging with arterial input function determination. [¹⁸F]SMBT-1 showed high brain uptake and a retention pattern c

SUBMITTER: Lopresti BJ 

PROVIDER: S-EPMC11542143 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature