Cardiac Matrix-Derived Granular Hydrogel Enhances Cell Function in 3D Culture.

ABSTRACT: Hydrogels derived from decellularized porcine myocardial matrix have demonstrated significant potential as therapeutic delivery platforms for promoting cardiac repair after injury. Our previous study developed a fibrin-enriched cardiac matrix hydrogel to enhance its angiogenic capacities. However, the bulk hydrogel structure may limit their full potential in cell delivery. Recently, granular hydrogels have emerged as a promising class of biomaterials, offering unique features such as a highly interconnected porous structure that facilitates nutrient diffusion and enhances cell viability. Several techniques have been developed for fabricating various types of granular hydrogels, among which extrusion fragmentation is particularly appealing due to its adaptability to many types of hydrogels,

SUBMITTER: Shaik R 

PROVIDER: S-EPMC11542188 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature