Principles of slowed hydrogen diffusion through a mucus layer.

ABSTRACT: The control of transport through mucus layers is a ubiquitous phenomenon in physiological systems. Mucus is often tasked with the mediation of passive, diffusive transport of small ionic species. However, questions remain regarding how mucin gel characteristics (charge density of the polymeric network, binding affinity of ions with mucus) govern the rate at which ions diffuse through mucus layers. Experimental studies measuring hydrogen diffusion through gastric mucus have provided conflicting results, and it is not clear if the rate of ionic diffusion through mucus layers is appreciably different than in aqueous environments (depending on experimental preparation). Here, we present a mathematical analysis of electrodiffussion of two ionic species (hydrogen and chloride) through a mucus la

SUBMITTER: Lewis OL 

PROVIDER: S-EPMC11542194 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature