Association between sulfur microbial diet and the risk of esophageal cancer: a prospective cohort study in 101,752 American adults.

ABSTRACT:

Background

Sulfur microbial diet (SMD) is a dietary pattern closely related to the intestinal load of sulfur-metabolizing microbes in humans. Diet and microbes may play an important role in the carcinogenesis of esophagus. However, epidemiological studies on SMD and esophageal cancer (EC) risk are scarce. Here, we evaluated this association based on a large American cohort.

Methods

In the cohort of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, a SMD score was calculated to evaluate participants' compliance of SMD pattern, with higher scores presenting greater adherence. Cox hazards regression model was used to explore the association between the SMD score and the incidence of EC, esophageal squamous cell carcinoma (ESCC), and esophageal adenocarc

SUBMITTER: Ren X 

PROVIDER: S-EPMC11542201 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature