Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells.

ABSTRACT:

Background

The placenta is essential for nutrient exchange and hormone production between the mother and the developing fetus and serves as an invaluable model for epigenetic research. Most epigenetic studies of the human placenta have used whole placentas from term pregnancies and have identified the presence of partially methylated domains (PMDs). However, the origin of these domains, which are typically absent in most somatic cells, remains unclear in the placental context.

Results

Using whole-genome bisulfite sequencing and analysis of histone H3 modifications, we generated epigenetic profiles of human cytotrophoblasts during the first trimester and at term, as well as human trophoblast stem cells. Our study focused specifically on PMDs. We found that genomic regions lik

SUBMITTER: Toh H 

PROVIDER: S-EPMC11542204 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature