The causal association between COVID-19 and ischemic stroke: a mendelian randomization study.

ABSTRACT:

Background

Current observational data indicates that ischemic stroke (IS) affects a significant proportion of people with COVID-19. The current study sought to evaluate the causal relationship between COVID-19 and IS.

Methods

A two-sample Mendelian randomization (2 S-MR) approach was used to probe the relationship between genetic determinants of three COVID-19 parameters (SARS-CoV-2 infection, COVID-19 hospitalization, and severe COVID-19) and the incidence of IS based on genome-wide association studies (GWAS) data. Using this 2 S-MR technique, expression quantitative trait loci (eQTL) and GWAS studies were further assessed for overlap to identify common causative genes associated with severe COVID-19 and IS.

Results

IVW approaches indicated the genetic variants linke

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11542230 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature