Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases.

ABSTRACT:

Background

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most efficient therapeutic options available to cure many hematological malignancies. However, severe complications derived from this procedure, including graft-versus-host disease (GVHD) and infections, can limit its success and negatively impact survival. Previous studies have shown that alterations in the microbiome are associated with the development of allo-HSCT-derived complications. However, most studies relied on single techniques that can only analyze a unique aspect of the microbiome, which hinders our ability to understand how microbiome alterations drive allo-HSCT-associated diseases.

Results

Here, we have applied multiple "omic" techniques (16S rRNA and shotgun sequencing, ta

SUBMITTER: Artacho A 

PROVIDER: S-EPMC11542268 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature