Observation of neutrophil extracellular traps in the development of diabetic nephropathy using diabetic murine models.

ABSTRACT:

Background

Diabetic nephropathy (DN) is a progressive complication among patients with diabetes and the most common cause of end-stage kidney disease. Neutrophil extracellular traps (NETs) are known to play a role in kidney disease, thus this study aimed to determine their role in the development of diabetic kidney disease using diabetic murine models.

Results

Protein and histological analyses revealed that db/db mice and streptozotocin DN models expressed no significant NET-related proteins, myeloperoxidase, citrullinated histone H3 (citH3), neutrophil elastase, and lymphocyte antigen 6 complex locus G6D (Ly6G). However, the inflamed individuals in the DN model showed that citH3 and Ly6G were highly deposited in the renal system based on immunohistochemistry images. In vitr

SUBMITTER: Jeon YH 

PROVIDER: S-EPMC11542270 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature