Levodopa Equivalent Daily Dosage: Geographical Variations and Real-Life Modules in Parkinson's Disease.

ABSTRACT:

Background

The Levodopa Equivalent Daily Dosage (LEDD) calculation algorithms help in capturing and harmonization of Parkinson's Disease (PD) therapies. Analyzing these updates is essential for validating their effectiveness.

Objective

To assess updated LEDD conversion factors in capturing the newer therapies in PD and therapy modules in different geographical cohorts.

Methods

Data were sourced from 10 Centers from 6 countries representing 2 different continents. The study compared the LEDD conversion factors proposed by Tomlinson et al and Jost et al, alongside investigating demographic disparities.

Results

The analysis involved 2943 subjects; 87% (n = 2577) met the UK Brain Bank criteria for PD. The LEDD differed significantly across methodologies (Tomlinson

SUBMITTER: Kukkle PL 

PROVIDER: S-EPMC11542276 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature