Sex Differences in Neuropsychiatric Symptoms in Alpha-Synucleinopathies: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Alpha-synucleinopathies, such as Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB), demonstrate sex differences with regard to prevalence, age of onset, and motor manifestations. Neuropsychiatric symptoms (NPS) are common early and late manifestations of these disorders.

Objectives

We aimed to describe sex differences in NPS across alpha-synucleinopathies.

Methods

We searched Web of Science Core collection databases to identify observational studies published between January 1, 2000, and June 1, 2022, reporting the prevalence or severity of NPS among individuals with a diagnosis of PD, PDD, or DLB. Prevalence and severity were pooled for each NPS according to sex using random-effects models.

Results

Two

SUBMITTER: Couture V 

PROVIDER: S-EPMC11542278 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature