Quality of Life after Deep Brain Stimulation in Parkinson's Disease: Does the Target Matter?

ABSTRACT:

Background

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is an accepted therapy for Parkinson's disease (PD) with disabling motor complications. For elderly patients with poorer cognition and postural instability, GPi has been proposed as the preferable DBS target based on expert opinion, arguing GPi-DBS may be less complicated by depression, apathy, worsened verbal fluency, and executive dysfunction, resulting in greater improvement in quality of life (QoL). However, data supporting such patient-tailored approach are lacking.

Objectives

The aims were to analyze whether the DBS target influences QoL in a PD cohort and a matched subgroup of frail patients with poor cognitive status and reduced postural stability, and whether

SUBMITTER: Murcia Carretero S 

PROVIDER: S-EPMC11542293 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature