Ethnic Differences in Atypical Parkinsonism-is South Asian PSP Different?

ABSTRACT:

Background

Progressive supranuclear palsy (PSP) is a progressive atypical parkinsonian condition that results in severe disability. There are few studies of PSP in patients of non-white European ancestry.

Objectives

We aim to perform deep phenotyping in a South Asian PSP cohort to uncover possible ethnic differences in disease characteristics.

Methods

Consecutive PSP patients had their clinical records reviewed for clinical features operationalized in the Movement Disorder Society (MDS)-PSP diagnostic criteria and relevant investigations, including imaging and genetic tests. Clinical variables were summarized by descriptive statistics and Kaplan-Meier curves were generated for survival analysis.

Results

Twenty-seven patients, comprising Indians (78%), Pakistani

SUBMITTER: Balint B 

PROVIDER: S-EPMC11542300 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature