Relationship between lactate levels and 28-day mortality in pediatric sepsis: results from the pediatric intensive care database.

ABSTRACT:

Objective

This study aimed to investigate the relationship between serum lactate levels at admission to the intensive care unit (ICU) and the clinical outcomes of children with sepsis.

Methods

We used the Pediatric Intensive Care (PIC) database to identify 288 pediatric patients with sepsis. We analyzed the relationship between lactate levels and hospital and ICU mortality in sepsis by establishing a segmented multivariable Cox regression model. We also conducted subgroup analysis as well as analyzed the restricted cubic spline curves.

Results

After adjusting for all potential confounding factors, an increase of 1 mmol/L in lactate levels was found to be associated with an 17% rise in the 28-day hospital mortality risk among sepsis patients (HR: 1.17, 95% CI: 1.08-1.2

SUBMITTER: Song Y 

PROVIDER: S-EPMC11542395 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature