Modifiable risk factors that mediate the effect of insomnia on the risk of low back pain: a network mendelian randomization study.

ABSTRACT:

Background

Low back pain (LBP) and insomnia are common global health issues, but their relationship and potential mediators remain unclear. This study aimed to explore the impact of insomnia on LBP using mendelian randomization (MR) methods and analyze the mediating role of modifiable factors.

Methods

Univariable MR (UVMR) analysis was employed to examine the causal relationship between insomnia and LBP, as well as the association between modifiable factors [smoking, alcohol consumption, body mass index (BMI), and type 2 diabetes (T2DM)] and LBP. Subsequently, multivariable MR (MVMR) analysis was conducted to explore the impact of insomnia on the mediation of LBP risk by modifiable factors.

Results

In the UVMR analysis, insomnia [odds ratio (OR) = 2.95, 95%CI: 2.33-3.

SUBMITTER: Lu W 

PROVIDER: S-EPMC11542420 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature