Cerebral hyperactivation across the Alzheimer's disease pathological cascade.

ABSTRACT: Neuronal dysfunction in specific brain regions or across distributed brain networks is a known feature of Alzheimer's disease. An often reported finding in the early stage of the disease is the presence of increased functional MRI (fMRI) blood oxygenation level-dependent signal under task conditions relative to cognitively normal controls, a phenomenon known as 'hyperactivation'. However, research in the past decades yielded complex, sometimes conflicting results. The magnitude and topology of fMRI hyperactivation patterns have been found to vary across the preclinical and clinical spectrum of Alzheimer's disease, including concomitant 'hypoactivation' in some cases. These incongruences are likely due to a range of factors, including the disease stage at which the cohort is examined, the b

SUBMITTER: Corriveau-Lecavalier N 

PROVIDER: S-EPMC11542485 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature