Are drivers recurring or ephemeral? observations from serial mapping of persistent atrial fibrillation.

ABSTRACT:

Aims

Rotational re-entries and ectopic foci, or 'drivers', are proposed mechanisms for persistent atrial fibrillation (persAF), but driver-based interventions have had mixed success in clinical trials. Selective targeting of drivers with multi-month stability may improve these interventions, but no prior work has investigated whether drivers can be stable on such a long timescale.

Objective

We hypothesized that drivers could recur even several months after initial observation.

Methods and results

We performed serial electrophysiology studies on paced canines (n = 18, 27-35 kg) at 1-, 3-, and 6 months post-initiation of continual persAF. Using a high-density 64-electrode catheter, we captured endocardial electrograms in the left atrium (LA) and right atrium (RA) to det

SUBMITTER: Hunt B 

PROVIDER: S-EPMC11542584 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature