Reduced Vancomycin Susceptibility in <i>Clostridioides difficile</i> Is Associated With Specific Ribotypes.

ABSTRACT:

Background

Reduced vancomycin (VAN) susceptibility in clinical Clostridioides difficile isolates is correlated with poor clinical outcomes. However, factors associated with infection with these strains are unknown. The goal of this study was to determine risk factors for reduced VAN susceptibility among clinical isolates of C. difficile.

Methods

This multicenter cohort study included adults with C. difficile infection (CDI) between 2016 and 2021. Clinical C. difficile isolates underwent agar dilution VAN susceptibility testing and ribotyping. Reduced susceptibility was defined as a minimum inhibitory concentration (MIC) > 2 µg/mL. Medical charts were reviewed for host, pathogen, and hospital characteristics and assessed for predictors of reduced V

SUBMITTER: Eubank TA 

PROVIDER: S-EPMC11542623 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature