Favipiravir pharmacokinetics in Thai adults with mild COVID-19: A sub-study of interpatient variability and ethnic differences in exposure.

ABSTRACT: This sub-study sought to characterize the pharmacokinetics (PK) of favipiravir (FPV) within Thai adults and quantitatively assess differences in exposure to those previously reported in other populations as a basis to understand putative differences in efficacy between studies conducted in different regions. It was nested within a prospective trial of adults with symptomatic COVID-19 infection without pneumonia receiving 1800 mg FPV twice-daily on day 1 and 800 mg twice-daily thereafter. Individual PK profiles were fitted with a one-compartment disposition model (first-order absorption). Eight adults (seven female) with a median age of 39 years and BMI of 27.9 kg/m² were included. Seven adults achieved plasma concentrations above the EC₉₀ in vitro target (25 mg/L), wi

SUBMITTER: Prasanchaimontri IO 

PROVIDER: S-EPMC11542727 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature