Systemic analysis shows that cold exposure modulates triglyceride accumulation and phospholipid distribution in mice.

ABSTRACT: Environmental exposure to cold is increasingly being associated with changes in metabolism. We developed and tested the hypothesis that exposure to cold drives systemic effects in lipid metabolism. Specifically, (i) that energy storage and provision adapts to the cold by altering triglyceride distribution and (ii) that membranes adapt to cold conditions by becoming more unsaturated. These hypotheses were designed to identify the underlying mechanisms that govern the response of mammalian systems to cold. To test these hypotheses, we used a metabolic network analysis. An established model of cold exposure was used, from which lipidomics data that represents the system was collected. The network analysis showed that triglyceride metabolism is altered on exposure to cold, with several smaller

SUBMITTER: James I 

PROVIDER: S-EPMC11542792 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature