Histone Methylation-Mediated Reproductive Toxicity to Consumer Product Chemicals in <i>Caenorhabditis elegans</i>: An Epigenetic Adverse Outcome Pathway (AOP).

ABSTRACT: The significance of histone methylation in epigenetic inheritance underscores its relevance to disease and the chronic effects of environmental chemicals. However, limited evidence of the causal relationships between chemically induced epigenetic changes and organismal-level effects hinders the application of epigenetic markers in ecotoxicological assessments. This study explored the contribution of repressive histone marks to reproductive toxicity induced by chemicals in consumer products in Caenorhabditis elegans, applying the adverse outcome pathway (AOP) framework. Triclosan (TCS) and tetrabromobisphenol A (TBBPA) exposures caused reproductive toxicity and altered histone methyltransferase (HMT) and histone demethylase (HDM) activities, increasing the level of trimethylation of

SUBMITTER: Kim J 

PROVIDER: S-EPMC11542887 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature