Mass Spectrometry Imaging of Two Neocortical Areas Reveals the Histological Selectivity of Schizophrenia-Associated Lipid Alterations.

ABSTRACT:

Background

Schizophrenia is a psychiatric disorder known to affect brain structure and functionality. Structural changes in the brain at the level of gross anatomical structures have been fairly well studied, while microstructural changes, especially those associated with changes in the molecular composition of the brain, are still being investigated. Of special interest are lipids and metabolites, for which some previous studies have shown association with schizophrenia.

Aim

To utilize a spatially resolved analysis of the brain lipidome composition to investigate the degree and nature of schizophrenia-associated lipidome alterations in the gray and white matter structures of two neocortical regions - the dorsolateral prefrontal cortex (Brodmann area 9, BA9) and the posterio

SUBMITTER: Osetrova M 

PROVIDER: S-EPMC11542914 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature