Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation.

ABSTRACT:

Background

CRP (C-reactive protein) is a prototypical acute phase reactant. Upon dissociation of the pentameric isoform (pCRP [pentameric CRP]) into its monomeric subunits (mCRP [monomeric CRP]), it exhibits prothrombotic and proinflammatory activity. Pathophysiological shear rates as observed in aortic valve stenosis (AS) can influence protein conformation and function as observed with vWF (von Willebrand factor). Given the proinflammatory function of dissociated CRP and the important role of inflammation in the pathogenesis of AS, we investigated whether shear stress can modify CRP conformation and induce inflammatory effects relevant to AS.

Methods

To determine the effects of pathological shear rates on the function of human CRP, pCRP was subjected to pathophysiologically

SUBMITTER: Zeller J 

PROVIDER: S-EPMC11542976 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature