The pan-cancer landscape of crosstalk between leukocyte transendothelial migration-related genes and tumor microenvironment relevant to prognosis and immunotherapy response.

ABSTRACT:

Background

Leukocyte transendothelial migration-related genes (LTEMGs) play a crucial role in the immune response and have been extensively studied in various pathological conditions, including inflammation, infection, and cancer. In recent years, increasing attention has been given to understanding the biological mechanisms of LTEMGs in the context of tumor progression and metastasis. The potential function of LTEMGs in cancer progression remains unclear. The aim of this study is to systematically delineate the relationship between LTEMGs and tumor prognosis and immune microenvironment at the pan-cancer level, providing new biomarkers for personalized immunotherapy.

Methods

The gene alteration, messenger RNA (mRNA) expression, and prognostic value of LTEMGs in pan-cancer we

SUBMITTER: Li H 

PROVIDER: S-EPMC11543035 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature