S100A1 overexpression stimulates cell proliferation and is predictive of poor outcome in ovarian cancer.

ABSTRACT:

Background

Members of the S100 gene family are frequently dysregulated in various cancers, including ovarian cancer (OC). Despite this, the prognostic implications of individual S100 genes in OC remain poorly understood. This study aimed to explore the prognostic significance of S100A1 expression in OC and assess its potential as a therapeutic target.

Methods

To investigate the role of S100A1 in OC, we utilized the Gene Expression Profiling Interactive Analysis (GEPIA) database and the University of ALabama at Birmingham Cancer Data Analysis Portal (UALCAN) database. Protein levels of S100A1 in OC tissues were assessed using western blotting and immunohistochemistry. Bioinformatics analyses were performed to correlate S100A1 expression with clinical outc

SUBMITTER: Jin W 

PROVIDER: S-EPMC11543041 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature