HDAC1: a promising target for cancer treatment: insights from a thorough analysis of tumor functions.

ABSTRACT:

Background

Many significant findings from recent studies have revealed the significance of histone deacetylase 1 (HDAC1) in the development of tumors and its strong association with tumor prognosis; these studies have mainly focused on one single cancer such as in lung cancer, breast cancer, and hepatocellular carcinoma (HCC). To date, there has been no comprehensive analysis and pan-analysis conducted from the overall perspective of cancer across all types. Hence, we analyzed public databases, conducted tube formation assay, and immunohistochemistry (IHC) staining of HDAC1 on six kinds of clinical samples to explore the prognostic and oncogenic effects of HDAC1 on 33 tumors for the first time. There currently remains a lack of efficient testing methods, therapies, and diagnostic a

SUBMITTER: Xie J 

PROVIDER: S-EPMC11543092 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature