SLAMF7 predicts prognosis and correlates with immune infiltration in serous ovarian carcinoma.

ABSTRACT:

Objective

Signaling lymphocytic activation molecule family members (SLAMFs) play a critical role in immune regulation of malignancies. This study aims to investigate the prognostic value and function of SLAMFs in ovarian cancer (OC).

Methods

The expression analysis of SLAMFs was conducted based on The Cancer Genome Atlas Ovarian Cancer Collection (TCGA-OV) and Gene Expression Omnibus (GEO) databases. Immunohistochemistry (IHC) was further performed on tissue arrays (n=98) to determine the expression of SLAMF7. Kaplan-Meier plotter and multivariate Cox regression model were used to evaluate the correlation of SLAMF7 expression with survival outcomes of patients. The molecular function of SLAMF7 in OC was further investigated using Gene Set Enrichment Analysis (GSEA).

Resul

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11543254 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature