Proteome-wide Mendelian randomization provides novel insights into the pathogenesis and druggable targets of osteoporosis.

ABSTRACT:

Background

With the aging population, the prevalence and impact of osteoporosis are expected to rise, and existing anti-osteoporosis agents have limitations due to adverse events. This study aims to discover novel drug targets for osteoporosis.

Methods

The protein data were obtained from the latest proteome-wide association studies (PWAS) including 54, 219 participants. The osteoporosis data were extracted from a GWAS meta-analysis, characterized by heel bone mineral density (HBMD) comprising 426,824 individuals. Mendelian randomization (MR) was the primary approach used to establish genetic causality between specific traits. Summary-data-based MR (SMR), colocalization analysis, heterogeneity test, and external validation were applied to ensure the findings were reliable. Th

SUBMITTER: Yan J 

PROVIDER: S-EPMC11543481 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature