Dual action electrochemical bandage operated by a programmable multimodal wearable potentiostat.

ABSTRACT: We have developed electrochemical bandage (e-bandage) prototypes that generate the reactive oxygen species hypochlorous acid (HOCl) or hydrogen peroxide (H₂O₂) for potential use to treat biofilm-infected wounds in humans. We have shown that both e-bandage-generated HOCl and H₂O₂ kill biofilms in vitro and in infected wounds on mice, with the former being more active in vitro. The H₂O₂-generating e-bandage, more so than the HOCl-generating e-bandage, was associated with improved healing of infected wounds. Here, a strategy in which H₂O₂ and HOCl are alternately generated-for dual action-was explored. The goal was to develop a programmable multimodal wearable potentiostat [PMWP] that can generate HOCl or

SUBMITTER: Bozyel I 

PROVIDER: S-EPMC11543506 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature