Polygenic risk score for drug-induced long QT syndrome: independent validation in a real-world patient cohort.

ABSTRACT:

Objective

Drug-induced long QT syndrome (diLQTS) is an adverse reaction from over 150 FDA-approved medications, posing the risk of triggering torsades de pointes and sudden death. While common genetic variants may modestly impact QT interval individually, their collective effect can significantly amplify risk of diLQTS. Consequently, this study aimed to validate a polygenic risk score (PRS) for diLQTS previously proposed by Strauss et al .

Methods

A retrospective cohort study was conducted utilizing patients from the Michigan Genomics Initiative prescribed 27 high-risk QT-prolonging drugs and an ECG during the prescription. The primary outcome was marked prolongation of the QTc interval (either >60 ms change from baseline or >500 ms absolute value) during treatment with a hi

SUBMITTER: Lopez-Medina AI 

PROVIDER: S-EPMC11543509 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature