Comparison of ¹⁸F-based PSMA radiotracers with [⁶⁸Ga]Ga-PSMA-11 in PET/CT imaging of prostate cancer-a systematic review and meta-analysis.

ABSTRACT:

Background

Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) has become an increasingly established imaging modality in the staging of prostate cancer (PCa). Numerous PSMA-based tracers are currently available, however, there is a lack of consensus on the optimal radiotracer(s) for PSMA PET/CT. This study aims to investigate whether Fluorine-18 (¹⁸F)-labelled PSMA PET/CT is significantly different from Gallium-68 (⁶⁸Ga) in primary diagnosis and/or secondary staging of prostate cancer following biochemical recurrence.

Methods

A critical review of MEDLINE, EMBASE, PubMed and Web of Science databases was performed in May 2023 according to the Preferred Reporting Items for Systematic Review and Meta-analys

SUBMITTER: Huang S 

PROVIDER: S-EPMC11543591 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature