Molecular mechanisms underpinning favourable physiological adaptations to exercise prehabilitation for urological cancer surgery.

ABSTRACT:

Background

Surgery for urological cancers is associated with high complication rates and survivors commonly experience fatigue, reduced physical ability and quality of life. High-intensity interval training (HIIT) as surgical prehabilitation has been proven effective for improving the cardiorespiratory fitness (CRF) of urological cancer patients, however the mechanistic basis of this favourable adaptation is undefined. Thus, we aimed to assess the mechanisms of physiological responses to HIIT as surgical prehabilitation for urological cancer.

Methods

Nineteen male patients scheduled for major urological surgery were randomised to complete 4-weeks HIIT prehabilitation (71.6 ± 0.75 years, BMI: 27.7 ± 0.9 kg·m²) or a no-intervention control (71.8 ± 1.1 years, BMI: 26

SUBMITTER: Blackwell JEM 

PROVIDER: S-EPMC11543602 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature