Addressing the antibody germline bias and its effect on language models for improved antibody design.

ABSTRACT:

Motivation

The versatile binding properties of antibodies have made them an extremely important class of biotherapeutics. However, therapeutic antibody development is a complex, expensive, and time-consuming task, with the final antibody needing to not only have strong and specific binding but also be minimally impacted by developability issues. The success of transformer-based language models in protein sequence space and the availability of vast amounts of antibody sequences, has led to the development of many antibody-specific language models to help guide antibody design. Antibody diversity primarily arises from V(D)J recombination, mutations within the CDRs, and/or from a few nongermline mutations outside the CDRs. Consequently, a significant portion of the variable domain of

SUBMITTER: Olsen TH 

PROVIDER: S-EPMC11543624 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature