Seasonality as a risk factor for deaths in Parkinson's disease.

ABSTRACT:

Background

According to growing evidence, sleep disruption harms biological processes and circadian homeostasis. Diurnal motor symptom volatility in Parkinson's Disease (PD) has been extensively studied. Few studies examined seasonal variability in PD symptoms, some showing it and others not.

Objective

To investigate whether PD patients' deaths follow a rhythmic pattern due to circadian rhythm alterations.

Methods

This study used only unidentified patient databases. People with PD, ICD10 code G20, in at least one death certificate field were selected. The Continuous Wavelet Transform and Fourier Transform were checked for oscillation and its duration.

Results

The 18-year analysis found 43,072 PD deaths. The Continuous Wavelet transform revealed a 351.87-day ann

SUBMITTER: Fonseca MCM 

PROVIDER: S-EPMC11543644 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature