An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-like experiences in adolescence.

ABSTRACT: In adolescence, psychotic-like experiences (PLE) may indicate potential prodromal symptoms preceding the onset of psychosis. Metabolomic studies have shown promise in providing valuable insights into predicting psychosis with enhanced precision compared to conventional clinical features. This study investigated metabolomic alterations associated with PLE in 76 depressed adolescents aged 14-20 years. Serum concentrations of 92 metabolites were analyzed with liquid chromatography-mass spectrometry. PLE were assessed using the Youth Experiences and Health (YEAH) questionnaire. The associations between PLE symptom dimensions (delusions, paranoia, hallucinations, negative symptoms, thought disorder, and dissociation) and metabolite concentrations were analyzed in linear regression models adjust

SUBMITTER: Kurkinen K 

PROVIDER: S-EPMC11543670 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature