Optical frequency domain imaging (OFDI) represents a novel technique for the diagnosis of giant cell arteritis.

ABSTRACT:

Background/objectives

Giant cell arteritis (GCA) is an inflammatory vascular disease in which prompt and accurate diagnosis is critical. The efficacy of temporal artery biopsy (TAB) is limited by 'skip' lesions and a delay in histological analysis. This first-in-man ex-vivo study aims to assess the accuracy of optical frequency domain imaging (OFDI) in diagnosing GCA.

Subjects/methods

29 TAB samples of patients with suspected GCA were submerged in 0.9% sodium chloride and an OFDI catheter was passed through the lumen to create cross-sectional images prior to histological analysis. The specimens were then preserved in formalin for histological examination. Mean intimal thickness (MIT) on OFDI was measured, and the presence of both multinucleate giant cells (MNGCs) and fragmen

SUBMITTER: Cox L 

PROVIDER: S-EPMC11543813 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature