Elevated ITGA3 expression serves as a novel prognostic biomarker and regulates tumor progression in cervical cancer.

ABSTRACT: Patients with advanced and recurrent cervical cancer often lack satisfactory treatment outcomes. Thus, it is necessary to seek reliable biomarkers that provide the ability to identify the disease at an early stage and predict the patient prognosis, providing new strategies for the treatment of cervical cancer. The sequencing data of ITGA3 were retrieved from public datasets. Immune infiltration and sensitivity of potential immunotherapy and chemotherapy have been analyzed between two subgroups. Functional analysis was applied to excavate the related pathways of ITGA3 in cervical cancer. Furthermore, the impact of ITGA3 in tumor progression has been verified in vitro. The results revealed that the level of ITGA3 was upregulated in cervical cancer, and was positively correlated with worse pr

SUBMITTER: Tan W 

PROVIDER: S-EPMC11543847 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature