Dental pulp stem cells promote genioglossus repair and systemic amelioration in chronic intermittent hypoxia.

ABSTRACT: Obstructive sleep apnea (OSA) leads to chronic intermittent hypoxia (CIH) and is not well addressed by current therapies. The genioglossus (GG) is the largest upper airway dilator controlling OSA pathology, making its repair a potential treatment. This study investigates dental pulp stem cells (DPSCs) in repairing GG injury in a CIH mouse model. We induced DPSCs to myogenic lineage cells (iDPSCs) and transplanted them into GG of CIH mice. DPSCs/iDPSCs grafts improved EMG^GG and muscle type transitions while reducing tumor necrosis factor α (TNF-α), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and creatine kinase (CK) levels, improving body weight. Moreover, iDPSCs increased Pax7⁺/Ki67⁺ and human-derived STEM121 cells in the GG compared with D

SUBMITTER: Zhang MH 

PROVIDER: S-EPMC11543914 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature