SPINK5 is a key regulator of eosinophil extracellular traps in head and neck squamous cell carcinoma.

ABSTRACT: Enhanced infiltration of eosinophils is observed surrounding solid tumors. Some studies indicate that Eosinophil extracellular traps (EETs) play a crucial role in tumor progression and metastasis. However, its specific role in head and neck squamous cell carcinoma (HNSCC) remains unclear. This study established a gene set associated with eosinophil differentiation, chemotaxis, and EETs release from previous research. Employing bioinformatics techniques, the expression and biological significance of these genes in HNSCC were analyzed. Briefly, unsupervised clustering based on expression patterns of 133 EETs-related genes to classify TCGA-HNSCC patients. Immune cell infiltration patterns were assessed using "ImmuCellAI" package. A prognostic model was constructed using ten algorithms, with E

SUBMITTER: Zhao C 

PROVIDER: S-EPMC11543977 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature