The node of Ranvier influences the <i>in vivo</i> axonal transport of mitochondria and signaling endosomes.

ABSTRACT: Efficient long-range axonal transport is essential for maintaining neuronal function, and perturbations in this process underlie severe neurological diseases. Nodes of Ranvier (NoR) are short, specialized unmyelinated axonal domains with a unique molecular and structural composition. Currently, it remains unresolved how the distinct molecular structures of the NoR impact axonal transport dynamics. Using intravital time-lapse microscopy of sciatic nerves in live, anesthetized mice, we reveal (1) similar morphologies of the NoR in fast and slow motor axons, (2) signaling endosomes and mitochondria accumulate specifically at the distal node, and (3) unique axonal transport profiles of signaling endosomes and mitochondria transiting through the NoR. Collectively, these findings provide importa

SUBMITTER: Tosolini AP 

PROVIDER: S-EPMC11544082 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature