Structural insights into the agonist selectivity of the adenosine A₃ receptor.

ABSTRACT: Adenosine receptors play pivotal roles in physiological processes. Adenosine A₃ receptor (A₃R), the most recently identified adenosine receptor, is expressed in various tissues, exhibiting important roles in neuron, heart, and immune cells, and is often overexpressed in tumors, highlighting the therapeutic potential of A₃R-selective agents. Recently, we identified RNA-derived N⁶-methyladenosine (m⁶A) as an endogenous agonist for A₃R, suggesting the relationship between RNA-derived modified adenosine and A₃R. Despite extensive studies on the other adenosine receptors, the selectivity mechanism of A₃R, especially for A₃R-selective agonists such as m⁶A and namodenoson, remained elusiv

SUBMITTER: Oshima HS 

PROVIDER: S-EPMC11544091 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature