Assessing erythroferrone and iron homeostasis in preeclamptic and normotensive pregnancies: A retrospective study.

ABSTRACT:

Introduction

Preeclampsia (PE) is a pregnancy-related disorder associated with maternal hypertension and placental dysfunction. A significant micronutrient during pregnancy is iron, which is important in cellular functions. While iron absorption increases in pregnancy, little is known about the exact mechanisms regulating maternal iron levels and transfer through the placenta in normal and complicated pregnancies.

Methods

In this retrospective study, we investigated the regulation of maternal and placental iron availability and storage, in normotensive and pregnancies complicated by early- or late-onset PE. Methods used were analysis of clinical records, ELISA analysis on plasma samples, immunofluorescent and Prussian Blue analysis on placenta biopsies.

Results

Focusi

SUBMITTER: Masoumi Z 

PROVIDER: S-EPMC11544558 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature