The impact of COVID-19 infection on multiple sclerosis disease course across 12 countries: a propensity-score-matched cohort study.

ABSTRACT:

Background

The relationship between coronavirus disease 2019 (COVID-19) infection and multiple sclerosis (MS) relapse and disease progression remains unclear. Previous studies are limited by small sample sizes and most lack a propensity-matched control cohort.

Objective

To evaluate the effect of COVID-19 infection on MS disease course with a large propensity-matched cohort.

Design

This multi-centre cohort study analysed relapse and disability outcomes post-COVID-19 infection after balancing covariates using a propensity score matching method. The study period was from the 11th of September 2019 to the 16th of February 2023. The mean follow-up period was 1.7 years.

Methods

Data were retrieved from the MSBase Registry. Propensity scores were obtained based on age

SUBMITTER: Levitz D 

PROVIDER: S-EPMC11544652 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature