Aptamer-Hytac Chimeras for Targeted Degradation of SARS-CoV-2 Spike-1.

ABSTRACT: The development of novel tools to tackle viral processes has become a central focus in global health, during the COVID-19 pandemic. The spike protein is currently one of the main SARS-CoV-2 targets, owing to its key roles in infectivity and virion formation. In this context, exploring innovative strategies to block the activity of essential factors of SARS-CoV-2, such as spike proteins, will strengthen the capacity to respond to current and future threats. In the present work, we developed and tested novel bispecific molecules that encompass: (i) oligonucleotide aptamers S901 and S702, which bind to the spike protein through its S1 domain, and (ii) hydrophobic tags, such as adamantane and tert-butyl-carbamate-based ligands. Hydrophobic tags have the capacity to trigger the degradation of t

SUBMITTER: Fabrega C 

PROVIDER: S-EPMC11544835 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature