Old Passengers as New Drivers: Chromosomal Passenger Proteins Engage in Translesion Synthesis.

ABSTRACT: Survivin is known for its dual biological role in apoptosis inhibition and mitotic progression. In addition to its being part of the chromosomal passenger complex (CPC), recent findings suggest additional roles for Survivin in the DNA damage response, further contributing to therapy resistance. In this study, we investigated the role of Survivin and the CPC proteins in the cellular response to irradiation with a focus on DNA replication processes. As is known, ionizing radiation leads to an increased expression of Survivin and its accumulation in nuclear foci, which we now know to be specifically localized to centromeric heterochromatin. The depletion of Survivin and Aurora B increases the DNA damage marker γH2AX, indicative of an impaired repair capacity. The presence of Survivin and the

SUBMITTER: Falke K 

PROVIDER: S-EPMC11544903 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature