Programmable Lipid Bilayer Tension-Control Apparatus for Quantitative Mechanobiology.

ABSTRACT: The biological membrane is not just a platform for information processing but also a field of mechanics. The lipid bilayer that constitutes the membrane is an elastic body, generating stress upon deformation, while the membrane protein embedded therein deforms the bilayer through structural changes. Among membrane-protein interplays, various channel species act as tension-current converters for signal transduction, serving as elementary processes in mechanobiology. However, in situ studies in chaotically complex cell membranes are challenging, and characterizing the tension dependency of mechanosensitive channels remains semiquantitative owing to technical limitations. Here, we developed a programmable membrane tension-control apparatus on a lipid bilayer system. This synthetic membrane sy

SUBMITTER: Matsuki Y 

PROVIDER: S-EPMC11544928 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature