Transcriptomic evidence for atopic dermatitis as a systemic disease in NC/Nga mice.

ABSTRACT:

Background

In the current study, we evaluated whether atopic dermatitis (AD) affects the entire body rather than being limited to skin barrier damage and inflammation. We hypothesized that medium-term exposure of distant organs to systemic inflammatory cytokines in sub-chronic inflammatory skin diseases has detrimental effects on distant tissues.

Results

Our findings demonstrated the dysregulation of genes and pathways associated with inflammation and the skin barrier, as well as genes and pathways involved in muscle development that respond to chemicals or stress in muscle tissues, all of which were reversed by hydrocortisone (Hc) administration. The expression of Ces1d showed significant differences during disease onset and after treatment in both skin and skeletal muscle,

SUBMITTER: Kim YW 

PROVIDER: S-EPMC11544999 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature