Genomic characteristics, disease outcome and heterologous vaccine effectiveness among cases with SARS CoV-2 infection.

ABSTRACT:

Background

In the pursuit of global health security, continuous monitoring of vaccine effectiveness across various viral strains emerges as a crucial imperative. The emergence of SARS-CoV-2 major variants of concern (VOCs), including Alpha, Beta, Delta, and Omicron, has added complexity to the COVID-19 vaccination landscape.

Objectives

To assess illness severity, evaluate vaccine efficacy across varying doses and types, and determine effectiveness against major VOCs within the population.

Methods

This retrospective cohort study, conducted in Abu Dhabi, United Arab Emirates, focuses on a cohort of 44,073 SARS-CoV-2 positive cases from February 2021 to May 2022, dominated by the Delta and Omicron variants. The study employed a nested case-control design, analyzing hospi

SUBMITTER: Abuyadek R 

PROVIDER: S-EPMC11545176 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature